Outcome of Postoperative Intratumoral Bleomycin Injection for Cystic Craniopharyngioma

Outcome of postoperative intratumoral bleomycin injection for cystic craniopharyngioma.

Total excision is a treatment of choice in preventing the relapse of craniopharyngioma, but for tumors involving an extensive area, it is often associated with an increased risk of complications. We have performed a partial or subtotal tumor removal followed by repeated injection of bleomycin into the remaining tumor through a subcutaneous reservoir as postoperative adjuvant therapy. A retrospe...

Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon.

OBJECTIVE To assess whether the cystic craniopharyngiomas can be controlled with the use of intratumoral applications of interferon alpha. METHOD Nineteen patients with the diagnosis of cystic craniopharyngioma were treated with intratumoral chemotherapy with interferon alpha from January 2002 to April 2006. All patients underwent placement of an intracystic catheter connected to an Ommaya re...

Direct percutaneous intratumoral bleomycin injection for palliative treatment of impending quadriplegia.

We describe a case of midcervical angiosarcoma causing compression of the cervical spinal cord, producing rapidly progressive neurologic deficits. The tumor had recurred despite previous resection and was refractory to radiation and chemotherapy. Shrinkage of the tumor by percutaneous embolization was not considered feasible. A single direct percutaneous intratumoral injection of 15 U of bleomy...

Intracystic Therapies for Cystic Craniopharyngioma in Childhood

INTRODUCTION Craniopharyngioma of childhood are commonly cystic in nature. An intracystic catheter insertion and subsequent instillation of substances inducing cyst shrinkage seems a beneficial strategy avoiding additional morbidity in a highly vulnerable brain location. METHODS A systematic review of the medical literature was performed to identify potentially relevant, all languages article...

Intratumoral Injection of CpG